(P10-15-26) The Effects of Fresh Mango Consumption on TMAO, Antioxidant Capacity and Lipid Profiles in Adults With Overweight and Obesity

Objectives: Trimethylamine N-oxide (TMAO) is a pro-inflammatory metabolite associated with increased risk of cardiovascular disease (CVD). Mango (Mangifera indica) is a nutrient-dense fruit rich in antioxidants, polyphenols, and bioactive compounds, which have been shown to improve vascular and metabolic health. However, limited research has investigated the effects of mango consumption on TMAO levels and associated cardiometabolic risk factors in adults with overweight or obesity. This study evaluated the effects of mango consumption on TMAO levels, total antioxidant capacity, lipid profiles, and body weight in adults with overweight and obesity.

Methods: Thirty-two participants (16 men and 16 women), aged 18-50 with body mass index (BMI) between 25-40 kg/m², completed a 4-week randomized crossover study. Participants consumed fresh mango (100 kcal/day) or isocaloric low-fat cookies, separated by a 4-week washout period. Data were analyzed using repeated-measure ANOVA with significance set at P ≤ 0.05.

Results: Although not statistically significant, interaction trends suggested a reduction in TMAO following mango consumption and an increase following cookie consumption (P = 0.076). HDL cholesterol decreased with cookie consumption in females (P = 0.045), while mango had no effect. Mango consumption also significantly reduced body weight and BMI in female participants (P < 0.05). No significant changes were observed in total antioxidant capacity, triglycerides, total cholesterol, or LDL cholesterol.

Conclusions: These findings suggest mango consumption may help reduce cardiovascular risk by lowering TMAO levels and decreasing body weight and BMI in females. Larger and longer-term studies are warranted to confirm its potential role in CVD risk reduction.

Funding Sources: Funded by the National Mango Board