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(OR05-07-26) Immediate Effects of Mid-Day Time-Restricted Eating on Continuous Glucose Monitoring-Derived Metabolic Metrics in Adults With Overweight and Obesity

Saturday, July 25, 2026
11:12 AM - 11:24 AM ET
Location: Maryland Ballroom C

    Presenting Author(s)

  • AE

    Armin Ezzati, PhD

    Principal Investigator
    University of Southern California
    Gainesville, Florida, United States

    Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • NA

    Nicholas Arce

    University of Southern California
    Los Angeles, California, United States

  • MV

    My Vu

    University of Southern California
    Los Angeles, California, United States

  • DB

    David Black, PhD

    University of Southern California
    Los Angeles, California, United States

Disclosure(s):
Armin Ezzati, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
Objectives: Time-restricted eating (TRE) may improve glycemic control. Yet, mid-day TRE (11am–7pm), a socially acceptable schedule, has not been studied in adults with overweight and obesity. Using continuous glucose monitoring (CGM), this trial examined the immediate effects of mid-day TRE on glucose variability and time above range.

Methods: Using data from a within-subject multiple-phase (ABA) trial, we conducted an analysis of six women with overweight and obesity (aged 42–65 years; BMI 29–34 kg/m2) who completed 10-day CGM self-monitoring and under normal eating windows (A1) and TRE (B) (11am–7pm; 4 days), and return to normal eating window (A2) phases. CGM metrics included 24-hour mean glucose and time above range ( >140 mg/dL). Exploratory analyses assessed associations between TRE-related changes in CGM metrics and sleep, calorie burned and heart rate variability (HRV).

Results: Compared with baseline (A1), the TRE phase (B) demonstrated reductions in glycemic values. Median (Q1, Q3) changes vs. A1 during TRE was −2.7 mg/d (−4.2, 1.8) for mean glucose and −3.3% (−4.5, 0.2) for TAR; similar patterns were observed for A2 vs. A1. Median daily calorie burned across phases (A1/B./A2) were 2,489/2,349/2,572 kcal; HRV 30/25/26 ms; and sleep 455/421/399 min. Exploratory analyses suggested positive trends between calories burned and HRV with TAR, whereas associations with sleep varied across phases.

Conclusions: In adults with overweight and obesity, a socially feasible mid-day TRE window led to immediate improvements in CGM-derived mean glucose and TAR. This is the first examination of the immediacy of TRE effect on continuous glucose tracings.

Funding Sources: The study is funded by a federal grant from the National Institutes of Health (NIMHHD) as a secondary analysis pilot award to AE.