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(OR02-04-26) Prevalence and Trends of Nutritional Deficiencies in Acute and Chronic Pancreatitis in the U.S.: Analysis of Real-World Data

Saturday, July 25, 2026
9:06 AM - 9:18 AM ET
Location: Maryland Ballroom A

    Presenting Author(s)

  • DB

    Djibril M. Ba, PhD, MPH

    Assistant Professor
    Penn State College of Medicine
    Hershey, Pennsylvania, United States

    Disclosure information not submitted.

    • Co-Author(s)

  • YZ

    Yue Zhang

    Johns Hopkins Bloomberg School of Public Health, Maryland, United States

  • TQ

    Tian Qiu

    Penn State College of Medicine, Pennsylvania, United States

  • XG

    Xiang Gao

    Fudan University, Shanghai, China (People's Republic)

  • PH

    Phil Hart

    The Ohio State University, Ohio, United States

  • VC

    Vernon M. Chinchilli

    Penn State College of Medicine, Pennsylvania, United States

  • KR

    Kristen M. Roberts

    The Ohio State University, Ohio, United States

Objectives: Individuals with acute pancreatitis (AP) and chronic pancreatitis (CP) are susceptible to nutritional deficiencies due to alterations in dietary intake, exocrine pancreatic insufficiency, and malabsorption, yet the prevalence, trends, and associated factors are poorly understood.

Methods: We conducted a serial cross-sectional study using data from the TriNetX Research Network in the U.S., 2017–2023. Individuals with AP and CP were identified using ICD-10 codes K85, K86.0, and K86.1. Controls were individuals without pancreatitis. Nutritional deficiencies (≥1), including anemia, protein malnutrition, vitamin B12 deficiency, and vitamin D deficiency, were identified using ICD-10 codes. Multivariable Poisson regression with robust variance estimated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) comparing pancreatitis groups with controls, adjusting for demographics, lifestyle factors, comorbidities, and social determinants of health.

Results: We identified 832,727 individuals: 83,032 AP, 12,534 CP, and 737,161 controls; mean (SD) age 47.7 (18.3) years. Nutritional deficiencies were more prevalent in Individuals with AP and CP than controls across all study years. Annual prevalence of ≥1 nutritional deficiency ranged 26–28% in AP, 37–43% in CP, and 10–12% in controls, showing stable or modestly increasing trends from 2017 to 2023. Multivariable-adjusted analyses showed a higher prevalence of nutritional deficiency in CP (aPR 1.71; 95% CI 1.67–1.75) and AP (aPR 1.49; 95% CI 1.47–1.52) compared with controls without pancreatitis.

Conclusions: Nutritional deficiencies were more prevalent among individuals with AP and CP than controls, with the highest prevalence in CP. These findings highlight the need for routine nutritional assessment and focused monitoring in individuals with AP and CP.

Funding Sources: Djibril M. Ba was supported by the NIDDK training grant 1K01DK140625-01.